Open Access Open Access  Restricted Access Subscription or Fee Access

Survival analysis of Breast and Small-Cell Lung Cancer Patients using Conditional Logistic Regression Models

Waheed Babatunde Yahya, Kurt Ulm

Abstract


In this study we investigated the use of (conditional) logistic regression (CLR) techniques to model failure-time data. The widely adopted semi-parametric approach of Cox proportional hazard (CPH) model has been reported to be a successive combination of the CLR approach. This implies that the CLR method could as well be appropriate to model event history situations. The use of this regression technique to model survival data is hereby examined. It is established that this regression method, apart from sharing some features with the Cox model, is an easy alternative to model survival data. The procedure is found to be more flexible to apply especially when time-varying effects of some prognostic factors are suspected. In the two situations considered, results from the CLR models are found to be similar with those obtained from the classical Cox models. Data sets on breast and small-cell lung cancer patients were used to demonstrate our results.

Keywords


Conditional logistic regression, Cox proportional hazard model, Log partial likelihood function, Odds-ratio

Full Text:

PDF


Disclaimer/Regarding indexing issue:

We have provided the online access of all issues and papers to the indexing agencies (as given on journal web site). It’s depend on indexing agencies when, how and what manner they can index or not. Hence, we like to inform that on the basis of earlier indexing, we can’t predict the today or future indexing policy of third party (i.e. indexing agencies) as they have right to discontinue any journal at any time without prior information to the journal. So, please neither sends any question nor expects any answer from us on the behalf of third party i.e. indexing agencies.Hence, we will not issue any certificate or letter for indexing issue. Our role is just to provide the online access to them. So we do properly this and one can visit indexing agencies website to get the authentic information.