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CFD Analysis of the Effect of Inlet Parameters on the Flow in Tangential-inlet Swirl Nozzle for Preparing Nano-drug

Kefeng Xiao, Zhihui Hao


Tangential-inlet swirl nozzle is a new kind of nozzle used for preparing nano-drug in SEDS process. Computational fluid dynamics (CFD) was utilized to simulate and analyze the flow in the nozzle. And thereby the effect of mass flow rate of SC-CO2 the flow in the nozzle for preparing nano-drug in SEDS process was studied in the paper. Based on the results obtained by CFD simulation, it can be inferred that mass flow rate of SC-CO2 is an important
parameter for tangential-inlet swirl nozzle in preparing nano-drug by SEDS process. The mass flow rate of SC-CO2 introduced from inlet1 affected the control of particle size and particle size distribution. Results indicate that when the mass flow rate of SC-CO2 is 7x10^4kg/s, the flow within the tangential-inlet swirl nozzle is most conducive for producing nanoparticle with narrow particle size distribution.


CFD simulation; SEDS; nano-drug; tangential-inlet swirl nozzle

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